This publication emphasizes the key cross cutting technological issues associated with instrumentation and control systems and human system interfaces that arise from the specific behaviour and operational characteristics of advanced small modular reactors (SMRs). It is intended to assist Member States in understanding current knowledge, practices, design and architecture, implementation, operating and maintenance related aspects with I&C systems in SMRs, as well as for discussing the challenges and issues that need to be resolved in this field in the first phases of design and implementation by Member States active in SMR development.