The treatment of wastewater presents the dual challenge of protecting public health and the environment. The presence of increasing amounts of chemical contaminants such as pharmaceuticals, petrochemicals, pesticides and dyes resulting from agricultural, industrial or municipal activities has potential negative impacts on ecosystems. Radiation technologies for treating different organic pollutants have been studied for many years, and their reliability and effectiveness have been demonstrated. This publication provides new insights into radiation treatment methodologies, particularly the evaluation of wastewater toxicity after radiation treatment, technoeconomic aspects of such treatment, and its integration with existing conventional technologies.