This publication gives practical information and examples of safety analysis principles and methods as well as the contents of licensing documentation needed to support application of IAEA safety standards to nuclear fuel cycle facilities. A systematic methodology is presented, covering the establishment of acceptance criteria, hazard evaluation, identification of postulated initiating events, analysis of accident sequences and consequences. Information is also provided on application of the results of the safety analysis in the design and operational phases, and on appropriate management system processes. The publication applies to all lifetime stages of relevant facilities and for modifications and upgrades. The information presented may be used for periodic safety reviews and consideration of extended lifetime of facilities. With respect to licensing documentation, the publication provides indicative contents and format of the safety analysis report as a higher level document that incorporates the information required at various steps in the licensing and relicensing process.