Description
In this publication the basic principles of radiation physics, imaging and non-imaging instrumentation used, measurement of the administered activity, calibration procedures and methods for obtaining quantitative information on the biodistribution of the radioactive drug to be used with radioisotopes relevant to therapy are specified. It also describes methods for segmentation and registration of images acquired at different time points, strategies for fitting and integration of activity measurements over the time of treatment, absorbed dose calculations and derived dosimetric indexes with methods to estimate the overall uncertainty of different radionuclide therapies. The aim of this book is to fill the existing gaps in education and training of medical physicists on methods for patient-specific dosimetry. The overall objective of this book is to highlight the tools and methodologies to assure that radiopharmaceutical therapy is implemented through a dosimetry-guided individualized treatment approach.
Keywords
Dosimetry for Radiopharmaceutical Therapy, RPT, Radiopharmaceuticals, Cancer, Radiation Dosimetry, Radiation Physics, Non-Imaging Instrumentation, Calibration Procedures, Quantitative Information, Biodistribution, Radioactive Drug, Radioisotopes, Segmentation, Registration of Images, Strategies for Fitting and Integration, Activity Measurements, Dose Calculations, Dosimetric Indexes, Radionuclide Therapies, Education and Training, Existing Gaps, Medical Physicists, Patient-Specific Dosimetry, Methodologies, Dosimetry-Guided Individualized Treatment Approach, Radiobiology, Traceability of Measured Dosimetry Data, Radioactive Decay, Radionuclide Emissions, Absorbed Dose Measurements, Metrology, Quantification of Activity, Tomographic Image Reconstruction, Dead Time Correction, Quantitative Imaging of Radionuclides, Imaging Surrogate Isotopes, Analysis of Temporally Varying Data, Pharmacokinetic Modelling, Clinical Radiobiological Modelling, Uncertainty Analysis, Dosimetry Protocol, Dose-Effect Relationships, Clinical Trials, Review
