This IAEA-WHO framework serves as an invaluable resource for countries in their ongoing efforts to strengthen their capacity for cancer control. Sharing the expertise of professionals from around the globe, it comprehensively outlines the fundamental principles of multidisciplinary cancer care. Additionally, it provides detailed descriptions of the essential infrastructure, human resources, and equipment necessary to deliver various cancer services. The purpose of this publication is to provide the context and requirements for specific services in a cancer centre, serving as guidance for evaluating and enhancing the quality of services. It is designed to support the growth and development of existing cancer centres, as well as in planning and establishment of new ones. By aligning with the main objectives of the IAEA Rays of Hope initiative, this publication contributes to the advancement of cancer care on a global scale.