In March 2023, at the invitation of the Chairs of the UN Framework Convention on Climate Change’s subsidiary bodies, the IAEA provided input to the first Global Stocktake under the Paris Agreement on climate change. The Global Stocktake is a key process for assessing progress towards the goals of the Paris Agreement and accelerating climate action. This publication presents a synthesis of the IAEA’s submission to the Stocktake in the form of a series of questions and answers addressing the contribution of nuclear energy to climate change mitigation, adaptation, finance, and technology, along with economic aspects and cross-cutting issues.