Description
This publication provides an overview of central nervous system (CNS) radiotracer development, discussing different aspects and stages of development. Non-invasive neuroimaging with radiotracers can provide functional information at the cellular level and contributes substantially to understanding the complex mechanisms of the functioning and pathophysiological processes in the human brain and is useful in certain diseases for patient stratification, treatment response monitoring and as an aided technique for drug development. The success of the development of clinically significant radiotracers depends on many factors such as the selected biological target, specificity and affinity of the radio ligand, pharmacokinetics of radiotracer and others. The information provided in the document will be useful to researchers, students and professionals engaged in the development and deployment of CNS radiotracers for clinical, research or drug development applications.
Keywords
Central Nervous System, CNS, Radiotracer Development, Bench to Bedside, Non-Invasive Neuroimaging, Functional Information, Cellular Level, Pathophysiological Processes, Human Brain, Patient Stratification, Treatment Response Monitoring, Aided Technique, Drug Development, Clinically Significant Radiotracers, Biological Target, Researchers, Students, Radioactive Tracers, Medical Examination, Diagnostic Use, Nuclear Medicine, Target Selection, Tracer Design, Clinical Translation, Quantification Methods, Valid Target Molecules, Biological Processes, Brain Targets, Emerging Targets, Lead Molecule Selection, Physiochemical and Pharmacological Requirements, Radiosynthesis Methods, Suitable Radionuclides, Radiolabelled Building Blocks, Quality Control, Quality Assurance, Vitro Methods, Metabolic Stability, Lipophilicity, Affinity for P-Glycoprotein, The Go/No Go Criteria, Preclinical Development, Animal Models, Imaging Types, Micro Dialysis, Kinetic Modelling Approach, Positron Emission Tomography, PET, Single Photon Emission Tomography, SPECT, Review
