This publication describes the nuclear security measures that were established and implemented to address nuclear security threats at the Africa Cup of Nations 2021 (Cameroon, 9 January to 6 February 2022). It details how the various competent authorities and agencies responsible for nuclear security implemented these measures with the support of the IAEA. It also highlights the technical and administrative requirements for developing the necessary organizational structure, nuclear security plans, strategies and concepts of operation. This publication is intended to be used by State authorities such as law enforcement, customs officials, security services and competent technical organizations, in their efforts to establish and implement nuclear security measures during a major public event.