This publication provides practical guidance on establishing a system of notification and authorization for the regulatory control over the use of radiation sources, including the provision for granting exemptions from regulatory requirements. It also provides examples of the notification and authorization procedures, detailing the documentation to be submitted by applicants, and provides a basis for the decisions to be made by regulatory bodies. It provides additonal examples of specific review and assessment procedures for applications requesting authorization for the use of radiation sources in diagnostic radiology, nuclear medicine, radiotherapy, industrial radiography, research and industrial irradiators, and gauges containing radioactive sources.