泰国科学家利用稳定同位素改善食品标签和营养计划

部分归功于使用稳定同位素技术收集到的科学数据,泰国消费者很快将获得更精确的食品营养标签和营养摄入量的建议。

在泰国食品营养标签更新和营养摄入量建议更新后,泰国一些人的饮食方式可能很快就会改变。科学家们现在正在使用稳定同位素技术作为帮助修订该国“膳食营养素参考摄入量”指南的努力的一部分。(照片:N. Jawerth/原子能机构)

泰国曼谷 —  部分归功于使用稳定同位素技术收集到的科学数据,泰国消费者很快将获得更精确的食品营养标签和营养摄入量的建议。这是政府努力修订其“膳食营养素参考摄入量” — 关于建议的每日营养摄入量以及哪些食物能够满足这一建议的指南 — 的一部分,目的是帮助确保人们获得正确的忠告。它将确保该国的营养政策和计划基于最新的数据。

“泰国上次更新其‘膳食营养素参考摄入量’的时间大约是15年前,但与营养有关的许多新科学已经出现,技术和方法已经发展,营养摄入量也发生了变化,” 曼谷玛希隆大学营养研究所前高级研究员兼前主任Emorn Udomkesmalee说。“我们现在拥有稳定同位素技术等工具,这意味着我们在指导人们的饮食时可以更加精确。”

自1996年以来一直与原子能机构合作的营养研究所是泰国首家提供营养标签全面分析服务的机构。其科学家们牵头开展研究,制订了分别于1989年和1998年首次推出的泰国“膳食营养素参考摄入量”和营养标签。他们现在正在使用稳定同位素技术(见“科学”栏)和其他方法开展一系列营养相关研究,这些研究构成了修订“膳食营养素参考摄入量”的基础。预计新的“膳食营养素参考摄入量”将从2018年底开始推出。

为建立营养和食物指南提供精确的数据

Udomkesmalee说,在制订任何营养指南时,精确度十分重要,因为“膳食营养素参考摄入量”影响着人们的日常生活。“当你为人们设定基于食物的饮食指南时,你需要确定,当你告诉人们‘四份这种食物’时,它确实符合某一年龄段和活动水平的人们对营养素和能量的需求”。

“膳食营养素参考摄入量”影响着一国与营养有关的一切,从食品营养标签,以食品为基础的饮食指南和健康计划,到食品研究与开发。“膳食营养素参考摄入量”基于涉及人体对能量、碳水化合物、蛋白质、脂肪、维生素和矿物质日常需求的丰富的国际和国内数据组合。

百科全书式的导则文件按照个体营养素进行分解,并根据年龄、性别以及(相关情况下)可能受到“膳食营养素参考摄入量”中营养建议显著影响的特殊群体对每个章节进一步细分。

该研究所负责督导能量消耗和身体成分研究的副教授Wantanee Kriengsinyos说,在制订国家“膳食营养素参考摄入量”时,科学家们常常从全球适用于人体的国际数据中提取数据,但这并不总能反映出一个国家的确切需求。

“比如,15年前,我们借用了‘膳食营养素参考摄入量’中有关西方国家能量的数据,但现在我们发现,该水平对泰国人和一般亚洲人太高。如果我们继续使用这些借来的陈旧数据,由于这种饮食产生的能量太密集,我们的体形会大一倍,” Kriengsinyos解释说。“我们需要根据人们的能量消耗来修订人们真正需要多少,我们正使用稳定同位素对这些值进行验证。”

虽然泰国可以改进现有数据以确保“膳食营养素参考摄入量”广泛适合其人口,但在其他情况下,必须收集具体数据以满足泰国特定群体的需求。

例如,血红蛋白病的情况就是如此,Udomkesmalee解释说。这是导致铁过剩的遗传缺陷。它影响全球约7%的人口,在非洲、地中海盆地和东南亚地区人口中十分常见。“如果泰国东北部三分之一的脆弱人口有这种状况,我们不得不问:铁强化食品会伤害他们吗?解决这个问题的惟一方法是使用稳定同位素技术来研究铁的吸收。”

科学家们已经发现,铁强化食品对血红蛋白病基因携带者并不是问题,但它对处于发病期的人却可能有问题。这项研究的结果将包含在泰国的“膳食营养素参考摄入量”中。

thailand-nutrition-isotope-analysis.jpg

科学家们使用同位素比质谱仪来评价样本,以进行与微量营养素摄入量、身体成分、母乳喂养实践以及身体利用和需要多少能量有关的营养研究。(照片:N. Jawerth/原子能机构)

东南亚的营养问题

泰国经修订的“膳食营养素参考摄入量”将有助于重塑全国的食物摄入量,但这些变化可能带来超越国界的影响。

“在修订‘膳食营养素参考摄入量’时,我们必须非常小心。如果你打算推出这样的改变,特别是作为一个东盟国家,那么,你用泰国‘膳食营养素参考摄入量’影响的就不仅仅是泰国,而且还有从泰国出口的所有食品和产品。如果营养标签上的‘膳食营养素参考摄入量’与其他国家制定的标准差别很大,人家就不会接受它,并且这可能会影响贸易,” Udomkesmalee说。“因此,必须认真审查和审核‘膳食营养素参考摄入量’,以确保它们有牢靠的科学基础,同时也确保它们能够顺利融入地区标准。”

在将于2018年12月10日至13日举行的了解营养不良双重负担促进有效干预问题国际专题讨论会上,将进一步讨论食品标签作为对超重和肥胖率上升的一项政策回应问题。

Precise data for setting up nutrition and food guidelines

When setting up any nutrition guidelines, precision is important because DRIs influence people’s everyday lives, Udomkesmalee said. “When you set food-based dietary guidelines for people, you need to make sure that when you tell people ‘four portions of this food,’ it really meets the requirements of the nutrients and the energy for people of a certain age and activity level.”

DRIs influence everything related to nutrition in a country, from nutrient labels on food, food-based dietary guidelines and health programmes to food research and development. They are based on a rich mix of international and national data related to the human body’s daily need for energy, carbohydrates, protein, fat, vitamins and minerals.

The encyclopedia-sized guidance document is broken down by individual nutrient and each chapter is further sub-divided according to age, gender, and, when relevant, special groups that can be significantly influenced by the nutrition recommendations in the DRIs.

When developing national DRIs, scientists often pull from international data that applies to human bodies globally, but this does not always capture a country’s exact needs, said Wantanee Kriengsinyos, associate professor at the Institute who oversees studies on energy expenditure and body composition.

“Fifteen years ago we borrowed DRI data on energy from western countries, for example, but now we are finding that the levels are too high for Thai people, and generally Asian populations. If we keep using this older, borrowed data, we’re going to be twice as huge because the diet is too energy dense,” explained Kriengsinyos. “We need to revise how much people really need based on their energy expenditure, and we are validating these values using stable isotopes.”

While Thailand can refine existing data to ensure the DRIs fit its population at large, in other cases, specific data has to be collected to address the needs of certain groups particular to Thailand.

This is the case, for instance, for hemoglobinopathy, explained Udomkesmalee. This is a genetic defect that causes iron overload. It affects around 7% of the world’s population and is most common in the populations of Africa, the Mediterranean basin and Southeast Asia. “If one-third of Thailand’s vulnerable population in the northeast has this condition, we have to ask: will iron fortified food hurt them? The only way to answer this is by using stable isotope techniques to study iron absorption.”

The scientists have found that iron-fortified food is not a problem in the carrier of the hemoglobinopathy genes, but it can be for those people with the full-blown disease. The findings of this study will be included in Thailand’s DRIs.

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Scientists use an isotope ratio mass spectrometer to evaluate samples for nutrition studies related to micronutrient intake, body composition, breastfeeding practices, and how much energy a body uses and needs. (Photo: N. Jawerth/IAEA)

Nutrition around Southeast Asia

Thailand’s revised DRIs will help reshape food intake throughout the country; however, these changes can have implications that go beyond borders.

“We have to be very careful when revising the DRIs. If you are going to launch changes like this, particularly as an ASEAN country, you are not only going to affect Thailand using Thai DRIs, but all the foods and products coming out of Thailand. If the DRIs on nutrition labelling are very different from what the other countries are setting as their standards, they won’t accept it and it could affect trade,” Udomkesmalee said. “So the DRIs will be carefully reviewed and checked to ensure they have a strong scientific basis, but also to ensure they will fit smoothly into regional standards.”

Food labelling as one policy response to growing rates of overweight and obesity will be further discussed during the upcoming International Symposium on Understanding the Double Burden of Malnutrition for Effective Interventions, to take place from 10 to 13 December 2018.