This Safety Guide provides guidance on the establishment of a national nuclear safety infrastructure as a key component of the overall preparations required for emerging nuclear power programmes. It provides recommendations, presented in the form of 200 sequential actions, on meeting the applicable IAEA safety requirements during the first three phases of the development of a nuclear power programme. It is intended for use by persons or organizations participating in the preparation and implementation of a nuclear power programme, including government officials and legislative bodies, regulatory bodies, operating organizations and external support entities.