This Safety Guide provides recommendations on how to meet the requirements of the IAEA International Basic Safety Standards with regard to irradiation facilities. It gives practical information on the safe design and operation of gamma, electron and X ray irradiators in accordance with these requirements, and discusses the beneficial applications of ionizing irradiation and how to avoid potential radiation hazards at industrial irradiators, including contamination arising from damaged radioactive sources. The Safety Guide is intended for use by the designers and operating organizations of these facilities and also by regulatory bodies.