This publication provides the basic contents of an education course for radiation oncology nurses. It is a minimally essential syllabus which can and should be adapted to the particular needs and characteristics of the centre and country. This syllabus provides specific guidelines for the education of nurses new to radiation oncology and for the practice of quality radiation oncology nursing care. This manual can assist with the organization and implementation of a course for the training of radiation oncology nurses in resource limited settings. It can also assist with articulation of the role of the radiation oncology nurse, justification of nursing staff positions in the department of radiation oncology, and with the evaluation of radiation oncology nurses’ performance.