This publication presents the proceedings of the international conference on topical issues in nuclear safety. The conference provided a unique forum to present and discuss the latest approaches, advances and challenges in the demonstration of the safety of nuclear power plants that are planned to be licensed and constructed in the near future, in particular those using water cooled reactors, including small and medium sized or modular reactors. The proceedings include the key insights and recommendations summarized by the Conference President, the executive summary of the conference including the key outcomes and recommendations attained together with the full conference programme.